Abstract | CONTEXT: The curative treatment of peptic ulcer is made available nowadays through the eradication of the bacterium Helicobacter pylori, which is associated with it, but the best therapeutic regimen is yet to be determined. OBJECTIVE: TYPE OF STUDY: Cross-sectional study. SETTING: Tertiary-care hospital. PATIENTS: One hundred and twenty nine outpatients, with active or healed peptic ulcers infected by Helicobacter pylori, diagnosed via endoscopy with confirmation via the urease test and histological examination, who had never undergone a regimen for the eradication of the bacterium. PROCEDURE: MAIN MEASUREMENTS: Efficacy of the treatment, with a check on the cure done via another endoscopy eight weeks after drug administration. The eradication of the bacterium was determined via the urease test and histological examination. Patients who were negative for both were considered to be cured. RESULTS: Eight patients failed to complete the study. The eradication rate according to intention to treat was 81% (104/129) and per protocol was 86% (104/121). CONCLUSION: The bismuth ranitidine compound associated with clarithromycin used for one week was shown to be a simple, effective and well-tolerated therapeutic regimen for the eradication of Helicobacter pylori.
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Authors | Jaime Natan Eisig, Fernando Marcuz Silva, Cláudio Hashimoto, Ethel Zimberg Chehter, Antonio Atilio Laudanna |
Journal | Sao Paulo medical journal = Revista paulista de medicina
(Sao Paulo Med J)
Vol. 121
Issue 1
Pg. 15-8
(Jan 02 2003)
ISSN: 1516-3180 [Print] Brazil |
PMID | 12751338
(Publication Type: Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Anti-Ulcer Agents
- ranitidine bismuth citrate
- Ranitidine
- Clarithromycin
- Bismuth
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Topics |
- Adolescent
- Adult
- Aged
- Anti-Bacterial Agents
(administration & dosage)
- Anti-Ulcer Agents
(administration & dosage)
- Bismuth
(administration & dosage)
- Brazil
- Clarithromycin
(administration & dosage)
- Cross-Sectional Studies
- Drug Administration Schedule
- Drug Therapy, Combination
- Female
- Helicobacter Infections
(drug therapy)
- Helicobacter pylori
- Humans
- Male
- Middle Aged
- Peptic Ulcer
(drug therapy, microbiology)
- Ranitidine
(administration & dosage, analogs & derivatives)
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