Factor V Leiden in pregnancies complicated by placental abruption.

Abstract

OBJECTIVE:

Recent studies suggest an increased prevalence of obstetric complications in female carriers of hereditary or acquired thrombophilias. The aim of the study was to determine if carriership of the factor V (FV) Leiden mutation (activated protein C [APC] resistance) is higher in women who have had of placental abruption during pregnancy.

DESIGN:

A retrospective case-control study.

SETTING:

University Hospital MAS, Malmö, Sweden.

METHODS:

A comparison of 102 women with placental abruption with 2371 prospectively collected controls. Carriership of FV Leiden was determined and the women were interviewed.

MAIN OUTCOME MEASURES:

Proportion of FV Leiden carriership, first degree heritage of thrombosis and previous placental abruption in cases and controls.

RESULTS:

Carriage of FV Leiden was found in 15.7% of women who have had placental abruption as compared with 10.8% of controls (P = 0.12, odds ratio [OR] = 1.5, 95% confidence interval [CI] = 0.9-2.7). Around 20% of women with placental abruption reported first degree heritage for venous thrombosis, as compared with 6.7% of controls (P < or = 0.001).

CONCLUSIONS:

FV Leiden carriership was not significantly different in women with placental abruption. However, there was an increased prevalence of first degree heritage for venous thrombosis in women with placental abruption, indicating a higher prevalence of thrombophilia among women with placental abruption.

• Authors: Martin Procházka, Catharina Happach, Karel Marsál, Björn Dahlbäck, Pelle G Lindqvist
• Journal: BJOG : an international journal of obstetrics and gynaecology (BJOG) Vol. 110 Issue 5 Pg. 462-6 (May 2003) ISSN: 1470-0328 [Print] England
• PMID: 12742330 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• factor V Leiden
• Factor V

Topics

• Abruptio Placentae (genetics)
• Activated Protein C Resistance (genetics)
• Adult
• Case-Control Studies
• Factor V (genetics)
• Female
• Humans
• Pregnancy
• Pregnancy Complications, Hematologic (etiology)
• Recurrence
• Retrospective Studies
• Thrombosis (genetics)