Abstract | BACKGROUND & AIMS: We have recently documented the efficacy of a highly concentrated probiotic preparation (VSL#3) in the prevention of flare-up in patients with chronic pouchitis. The aim of this study was to compare probiotic therapy with VSL#3 versus placebo in the ability to prevent the onset of acute pouchitis during the first year after ileal pouch-anal anastomosis. METHODS: Forty consecutive patients who underwent ileal pouch-anal anastomosis for ulcerative colitis were randomized to receive either VSL#3 (1 packet containing 900 billion bacteria/day) (n = 20) or an identical placebo (n = 20) immediately after ileostomy closure for 1 year. The patients were assessed clinically, endoscopically, and histologically after 1, 3, 6, 9, and 12 months. Health-related quality of life was assessed using the Inflammatory Bowel Disease Questionnaire. RESULTS: Two of the 20 patients (10%) treated with VSL#3 had an episode of acute pouchitis compared with 8 of the 20 patients (40%) treated with placebo (log-rank test, z = 2.273; P < 0.05). Treatment with VSL#3 determined a significant improvement in Inflammatory Bowel Disease Questionnaire score, whereas this was not the case with placebo. CONCLUSIONS:
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Authors | Paolo Gionchetti, Fernando Rizzello, Ulf Helwig, Alessandro Venturi, Karen Manon Lammers, Patrizia Brigidi, Beatrice Vitali, Gilberto Poggioli, Mario Miglioli, Massimo Campieri |
Journal | Gastroenterology
(Gastroenterology)
Vol. 124
Issue 5
Pg. 1202-9
(May 2003)
ISSN: 0016-5085 [Print] United States |
PMID | 12730861
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Topics |
- Acute Disease
- Adolescent
- Adult
- Aged
- Chronic Disease
- Colitis, Ulcerative
(surgery)
- Defecation
- Double-Blind Method
- Enterobacteriaceae
- Female
- Humans
- Intestines
(microbiology)
- Male
- Middle Aged
- Patient Selection
- Postoperative Complications
(drug therapy, prevention & control)
- Pouchitis
(drug therapy, prevention & control)
- Probiotics
(administration & dosage, adverse effects)
- Quality of Life
- Treatment Outcome
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