Mechanism of action of IVIG and anti-D in ITP.

Abstract

Infusion of large amounts of intravenous immunoglobulin (IVIG) or polyclonal anti-D can reverse thrombocytopenia in patients with idiopathic thrombocytopenic purpura within hours of the administration of these products. It has been suggested that the effects of IVIG appear to far outlast several half-lives of the product. Several mechanisms have been proposed to explain both the acute and long term effects of IVIG. These will be discussed in this review.

• Authors: Alan H Lazarus, Andrew R Crow
• Journal: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis (Transfus Apher Sci) Vol. 28 Issue 3 Pg. 249-55 (Jun 2003) ISSN: 1473-0502 [Print] England
• PMID: 12725951 (Publication Type: Journal Article, Review)

Chemical References

• Antigens, CD
• Fc gamma receptor IIB
• Immunoglobulins, Intravenous
• Isoantibodies
• RHO(D) antibody
• Receptors, IgG
• Rho(D) Immune Globulin

Topics

• Antigens, CD (physiology)
• Humans
• Immune System (drug effects)
• Immunoglobulins, Intravenous (pharmacology, therapeutic use)
• Isoantibodies (pharmacology, therapeutic use)
• Mononuclear Phagocyte System (drug effects)
• Purpura, Thrombocytopenic, Idiopathic (drug therapy)
• Receptors, IgG (physiology)
• Rho(D) Immune Globulin