Systemic capillary leak syndrome after granulocyte colony-stimulating factor (G-CSF).

Abstract

Capillary leak syndrome (CLS) commonly occurs in the intensive care setting. CLS is seen in conditions such as septic shock or may result from conditions such as multitrauma and pancreatitis, which result in the systemic inflammatory response syndrome (SIRS). We present two cases in which both patients suffered with CLS, which we believe was caused following administration of granulocyte colony-stimulating factor, to our knowledge not described in the intensive care patient previously. We discuss how these patients management differs from other intensive care unit patients with CLS and how it is important to diagnose this condition early in haematological oncology cases.

• Authors: Ian Rechner, Finella Brito-Babapulle, Jonathan Fielden
• Journal: The hematology journal : the official journal of the European Haematology Association (Hematol J) Vol. 4 Issue 1 Pg. 54-6 ( 2003) ISSN: 1466-4860 [Print] England
• PMID: 12692521 (Publication Type: Case Reports, Journal Article)

Chemical References

• Granulocyte Colony-Stimulating Factor
• Thalidomide
• Vincristine
• Dexamethasone
• Doxorubicin
• Cyclophosphamide
• Methylprednisolone
• Hydroxyurea

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Capillary Leak Syndrome (chemically induced, drug therapy, physiopathology)
• Combined Modality Therapy
• Critical Care
• Cyclophosphamide (therapeutic use)
• Dexamethasone (administration & dosage)
• Doxorubicin (administration & dosage)
• Dyspnea (etiology)
• Edema (etiology, physiopathology)
• Fasciitis, Necrotizing (etiology)
• Fatal Outcome
• Granulocyte Colony-Stimulating Factor (adverse effects, therapeutic use)
• Hematopoietic Stem Cell Mobilization (adverse effects)
• Humans
• Hydroxyurea (administration & dosage)
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive (complications, drug therapy, therapy)
• Male
• Methylprednisolone (therapeutic use)
• Middle Aged
• Models, Biological
• Multiple Myeloma (complications, drug therapy, therapy)
• Peripheral Blood Stem Cell Transplantation
• Thalidomide (therapeutic use)
• Vasculitis, Leukocytoclastic, Cutaneous (chemically induced)
• Vincristine (administration & dosage)