Abstract | BACKGROUND: METHODS: A randomized double-blind, double-dummy, controlled trial was conducted in 100 patients to compare the antispasmodic effects of hyoscine-N-butylbromide administered intramuscularly and a placebo solution administered intraluminally by means of the endoscope, and also the effects of a placebo solution administered intramuscularly with those of a peppermint oil solution administered intraluminally. The percent change in diameter of the pyloric ring before and after the administrations was defined as the opening ratio, and the percent change in diameter between the maximally and minimally opened pyloric ring states was defined as the contraction ratio. Time until disappearance of the contraction ring(s) in the gastric antrum and side effects of the drugs were also determined. RESULTS: CONCLUSIONS:
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Authors | Naoki Hiki, Hanzou Kurosaka, Yusuke Tatsutomi, Shouji Shimoyama, Eiichi Tsuji, Junichi Kojima, Nobuyuki Shimizu, Hitoshi Ono, Tatsuo Hirooka, Chiaki Noguchi, Ken-Ichi Mafune, Michio Kaminishi |
Journal | Gastrointestinal endoscopy
(Gastrointest Endosc)
Vol. 57
Issue 4
Pg. 475-82
(Apr 2003)
ISSN: 0016-5107 [Print] United States |
PMID | 12665756
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Parasympatholytics
- Plant Oils
- Butylscopolammonium Bromide
- peppermint oil
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Butylscopolammonium Bromide
(therapeutic use)
- Double-Blind Method
- Endoscopy, Gastrointestinal
- Female
- Humans
- Male
- Mentha piperita
- Middle Aged
- Muscle Contraction
(drug effects)
- Muscle, Smooth
(drug effects)
- Parasympatholytics
(pharmacology, therapeutic use)
- Plant Oils
(pharmacology, therapeutic use)
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