Abstract | BACKGROUND/PURPOSE: METHODS: RESULTS: A total of 13 patients were evaluated in this study. All 3 patients enrolled without being on ECLS rapidly transitioned to ECLS. The study, therefore, effectively evaluated PILG (n = 8) versus standard ventilation (control, n = 5) on ECLS. Mean (+/- SE) gestational age was 37 +/- 1 weeks and weight was 3.1 +/- 0.1 kg. Time on ECMO was 9.8 +/- 2.3 days in the PILG and 14.5 +/- 3.5 days (P =.58) in the control group. Survival rate in the PILG group was 6 of 8 (75%), whereas survival rate was 2 of 5 (40%) in the control group (P =.50). The number of days free from the ventilator in the first 28 days (VFD) was 6.3 +/- 3.3 days with PILG and 4.6 +/- 4.6 days with control (P =.9). Causes of death in the PILG group included sepsis and renal failure in one patient and pulmonary hypertension in the other. There were no safety issues, and the deaths in the PILG group did not appear to be related to the administration of perflubron. CONCLUSIONS: These data show that PILG can be performed safely. The survival rate, VFD, and time on ECMO data, although not conclusive, are encouraging and indicate the need for a definitive trial of this novel intervention in these neonates with high mortality.
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Authors | Ronald B Hirschl, William Fox Philip, L Glick, Jay Greenspan, Kendra Smith, Anne Thompson, Jay Wilson, N Scott Adzick |
Journal | Journal of pediatric surgery
(J Pediatr Surg)
Vol. 38
Issue 3
Pg. 283-9; discussion 283-9
(Mar 2003)
ISSN: 1531-5037 [Electronic] United States |
PMID | 12632336
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Copyright | Copyright 2003, Elsevier Science (USA). All rights reserved. |
Chemical References |
- Fluorocarbons
- Hydrocarbons, Brominated
- Pulmonary Surfactants
- Nitric Oxide
- perflubron
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Topics |
- Combined Modality Therapy
- Extracorporeal Membrane Oxygenation
- Female
- Fluorocarbons
(administration & dosage, therapeutic use)
- Hernia, Diaphragmatic
(mortality, surgery, therapy)
- Hernias, Diaphragmatic, Congenital
- High-Frequency Ventilation
- Humans
- Hydrocarbons, Brominated
- Infant, Newborn
- Liquid Ventilation
- Lung
(growth & development)
- Male
- Nitric Oxide
(therapeutic use)
- Pilot Projects
- Prospective Studies
- Pulmonary Surfactants
(therapeutic use)
- Respiration, Artificial
- Survival Rate
- Treatment Outcome
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