Abstract | BACKGROUND: METHODS: Thirty-two patients scheduled for elective laparoscopic cholecystectomy were recruited for a prospective, randomized, double-blinded comparative study. They were allotted randomly to two groups: placebo or clonidine. Patients in the placebo group (n = 16) were premedicated with oral antacid ( alugel hydroxide 300 mg), while those in the clonidine group (n = 16) were premedicated with oral clonidine 150 micro g before anesthesia. Analysis of heart rate variability was used to quantify the control of heart rate at baseline, and during the pneumoperitoneum and recovery periods. Time of the first request for postoperative analgesic and cumulative analgesic requirements in 24 h were recorded. Data are expressed as mean +/- SD. RESULTS: Heart rate variability was reduced in the pneumoperitoneum and postoperative period in the placebo group. Clonidine resulted in a greater perioperative ( pneumoperitoneum period) power at all frequency ranges compared with placebo (671.5 +/- 470.5 vs. 55.1 +/- 51.6 ms2/Hz for total power variability, 170.1 +/- 94.4 vs. 16.9 +/- 21.1 ms2/Hz for low-frequency variability and 206.1 +/- 95.7 vs. 16.4 +/- 15.1 ms2/Hz for high-frequency variability, P < 0.05). The postoperative analgesic requirement was less (2.3 +/- 0.8 vs. 3.2 +/- 1.2 dose, P < 0.05) in comparison with the placebo group. CONCLUSION:
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Authors | H-P Yu, S-S Hseu, H-W Yien, Y-H Teng, K-H Chan |
Journal | Acta anaesthesiologica Scandinavica
(Acta Anaesthesiol Scand)
Vol. 47
Issue 2
Pg. 185-90
(Feb 2003)
ISSN: 0001-5172 [Print] England |
PMID | 12631048
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright Acta Anaesthesiologica Scandinavica 47 (2003) |
Chemical References |
- Adrenergic alpha-Agonists
- Clonidine
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Topics |
- Adrenergic alpha-Agonists
- Adult
- Anesthesia, General
- Cholecystectomy, Laparoscopic
- Clonidine
- Double-Blind Method
- Electrocardiography
(drug effects)
- Female
- Heart Rate
(drug effects, physiology)
- Humans
- Male
- Pain Measurement
- Pain, Postoperative
(prevention & control)
- Pneumoperitoneum, Artificial
- Preanesthetic Medication
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