Abstract |
Abnormalities of CD40 ligand have been demonstrated in various kinds of diseases. Our objective was to determine serum soluble CD40 ligand (sCD40L) levels in patients with mixed connective tissue disease ( MCTD). Serum sCD40L levels of 23 patients with MCTD and 21 healthy individuals were measured with specific enzyme-linked immunosorbent assays. Serum levels of sCD40L were significantly higher in patients with MCTD than in healthy individuals (median 0.179 ng/ml vs 0.99 ng/ml, 25th-75th percentile; 0.117-0.296 ng/ml vs 0.82-1.70 ng/ml, P<0.005), whereas there were no significant correlation between elevated serum sCD40L levels and clinical or serological features in patients with MCTD. These results suggest that sCD40L plays a role in the pathogenesis of MCTD. Further studies are needed to clarify this.
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Authors | M Jinnin, H Ihn, N Yazawa, Y Asano, K Yamane, K Tamaki |
Journal | Clinical rheumatology
(Clin Rheumatol)
Vol. 22
Issue 1
Pg. 37-9
(Feb 2003)
ISSN: 0770-3198 [Print] Germany |
PMID | 12605316
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- CD40 Ligand
(blood)
- Case-Control Studies
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Male
- Mixed Connective Tissue Disease
(blood, physiopathology)
- Solubility
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