Abstract | OBJECTIVES: We have previously observed the inhibitory effect of ferulic acid on rat tongue carcinogenesis. In this study, we investigated the modifying effects of a novel geranylated derivative, ethyl 3-(4'-geranyloxy-3'-methoxyphenyl)-2-propenoate (EGMP), synthesized from ferulic acid on tongue carcinogenesis initiated with 4-nitroquinoline 1-oxide (4-NQO). METHODS: RESULTS: At week 30, the incidence and multiplicity of tongue squamous cell carcinoma were significantly reduced by feeding of a 2% EGMP diet. EGMP feeding (2% in diet) elevated tongue GST activity and lowered QR activity in the tongue. Dietary EGMP decreased the expression of cell proliferation biomarker expression. Interestingly, EGMP feeding altered iNOS expression in the invasive parts of carcinoma. CONCLUSIONS: These results suggest that EGMP, when given at the 2% dose level during the promotion phase, exerts a chemopreventive action against tongue tumorigenesis through modification of cell proliferation activity and/or detoxifying enzymatic activity.
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Authors | Takuji Tanaka, Hiroyuki Kohno, Eisaku Nomura, Hisaji Taniguchi, Takuo Tsuno, Hiroyuki Tsuda |
Journal | Oncology
(Oncology)
Vol. 64
Issue 2
Pg. 166-75
( 2003)
ISSN: 0030-2414 [Print] Switzerland |
PMID | 12566915
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2003 S. Karger AG, Basel |
Chemical References |
- 4-nitroquinolone-1-oxide
- Biomarkers, Tumor
- Carcinogens
- Coumaric Acids
- Free Radical Scavengers
- Proliferating Cell Nuclear Antigen
- Quinolones
- Terpenes
- ethyl-3-(4'-geranyloxy-3'-methoxyphenyl)-2-propenoate
- 4-Nitroquinoline-1-oxide
- ferulic acid
- Nitric Oxide Synthase
- Nitric Oxide Synthase Type II
- Nos2 protein, rat
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Topics |
- 4-Nitroquinoline-1-oxide
- Animals
- Biomarkers, Tumor
(analysis)
- Carcinogens
- Cell Division
(drug effects)
- Coumaric Acids
(pharmacology)
- Free Radical Scavengers
(pharmacology)
- Gene Expression Regulation, Enzymologic
(drug effects)
- Gene Expression Regulation, Neoplastic
(drug effects)
- Immunohistochemistry
- Incidence
- Male
- Nitric Oxide Synthase
(analysis, antagonists & inhibitors)
- Nitric Oxide Synthase Type II
- Proliferating Cell Nuclear Antigen
(analysis)
- Quinolones
- Rats
- Rats, Inbred F344
- Terpenes
(chemical synthesis, pharmacology)
- Tongue Neoplasms
(chemically induced, enzymology, prevention & control)
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