Anti-herpes activity of adenine arabinoside monophosphate.

Abstract

Adenine arabinoside monophosphate (Ara-AMP) demonstrated antiviral activity equivalent to adenine arabinoside (Ara-A) against herpesvirus Types 1 and 2 in tissue culture. Against established herpes virus Type 1 epithelial keratitis in rabbits, Ara-AMP 2 per cent was comparable in efficacy to Ara-A 3 per cent, and Ara-AMP 20 per cent was superior to Ara-A 3 per cent. These results are especially significant in that Ara-A's high solubility will permit (1) more concentrated formulations to be presented topically and (2) adequate absorption by parenteral routes with smaller fluid loads than required for Ara-A.

• Authors: J D Trobe, Y Centifanto, Z S Zam, E Varnell, H E Kaufman
• Journal: Investigative ophthalmology (Invest Ophthalmol) Vol. 15 Issue 3 Pg. 196-9 (Mar 1976) ISSN: 0020-9988 [Print] United States
• PMID: 1254407 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Purine Nucleosides
• Adenosine Monophosphate
• Vidarabine

Topics

• Adenosine Monophosphate (analogs & derivatives, therapeutic use)
• Administration, Topical
• Animals
• Cytopathogenic Effect, Viral (drug effects)
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical
• Herpesviridae (drug effects)
• Keratitis, Dendritic (drug therapy)
• Purine Nucleosides (therapeutic use)
• Rabbits
• Vidarabine (analogs & derivatives, therapeutic use)