Effects of ganglioside GM1 on reduction of brain edema and amelioration of cerebral metabolism after traumatic brain injury.

Abstract

OBJECTIVE:

To observe the effects of ganglioside GM1 on reduction of brain edema and amelioration of cerebral metabolism after traumatic brain injury (TBI).

METHODS:

An acute experimental closed TBI model in rats was induced by a fluid-percussion brain injury model. At five and sixty minutes after TBI, the animals were intraperitoneally injected by ganglioside GM1 (30 mg/kg) or the same volume of saline. At the 6th hour after TBI, effects of ganglioside GM1 or saline on changes of mean arterial pressure (MAP), contents of water, lactic acid (LA) and lipid peroxidation (LPO) in the injured cerebral tissues were observed.

RESULTS:

After TBI, MAP decreased and contents of water, LA and LPO increased in brain injury group; however, MAP was back to normal levels and contents of water, LA and LPO decreased in ganglioside GM1 treated group, compared with those in brain injury group (P < 0.05). No significant difference between the saline treated group and the brain injury group (P > 0.05) was observed.

CONCLUSIONS:

Ganglioside GM1 does have obvious neuroprotective effect on early TBI.

• Authors: Zhi-gang Chen, Yi-cheng Lu, Cheng Zhu, Guang-ji Zhang, Xue-hua Ding, Ji-yao Jiang
• Journal: Chinese journal of traumatology = Zhonghua chuang shang za zhi (Chin J Traumatol) Vol. 6 Issue 1 Pg. 23-7 (Feb 2003) ISSN: 1008-1275 [Print] China
• PMID: 12542960 (Publication Type: Evaluation Study, Journal Article)

Chemical References

• Lactic Acid
• G(M1)ganglioside synthetase
• Hexosyltransferases

Topics

• Animals
• Brain (metabolism)
• Brain Edema (etiology, prevention & control)
• Brain Injuries (complications, metabolism)
• Disease Models, Animal
• Hexosyltransferases (therapeutic use)
• Lactic Acid (analysis)
• Lipid Peroxidation
• Male
• Random Allocation
• Rats
• Rats, Sprague-Dawley