Heart transplant for anomalous origin of left coronary artery from pulmonary artery.

Abstract

Anomalous origin of the left coronary artery from the pulmonary artery is a congenital coronary artery malformation most commonly present in infancy. A variety of surgical procedures have been described to achieve physiological correction of the coronary flow abnormalities. These techniques are effective as long as there is potential for myocardial recovery. However the sequelae of chronic myocardial ischemia that characterize this entity often irreversibly damage the heart and preclude correction and palliation of the native anomaly. In this type of setting, heart transplantation is a realistic option. Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) occasionally presents in adulthood. Anatomic repair with a two coronary artery system may not be optimal in patients presenting with ischemic cardiomyopathy. We report an adult patient with platelet factor 4 (PF4) antibodies who underwent orthotopic heart transplantation (OHT) for ALCAPA.

• Authors: Kiron K S Nair, Lawrence S Zisman, Ellis Lader, Aneta Dimova, Charles C Canver
• Journal: The Annals of thoracic surgery (Ann Thorac Surg) Vol. 75 Issue 1 Pg. 282-4; discussion 284-5 (Jan 2003) ISSN: 0003-4975 [Print] Netherlands
• PMID: 12537235 (Publication Type: Case Reports, Journal Article)

Chemical References

• Autoantibodies
• Platelet Factor 4

Topics

• Autoantibodies (analysis)
• Coronary Vessel Anomalies (surgery)
• Female
• Heart Transplantation
• Humans
• Middle Aged
• Platelet Factor 4 (immunology)
• Pulmonary Artery (abnormalities)