Abstract | OBJECTIVE: METHODS: RESULTS: All patients got endurable engraftment. The median time of recovery of neutrophil count to >or= 1 x 10(9)/L was 14 days (range 12 approximately 18 days). The median time to achieve a platelet count >or= 20 x 10(9)/L without transfusion was 13 days (range 11 approximately 65 days). Seven of the 14 patients developed aGVHD, 4 being in the grade I and 3 being in grade II. Three of the evaluable 9 patients developed extensive chronic GVHD. Two patients died of relapsed leukemia. One patient received secondary PBSCT from hte same donor because of ill engraftment and developed grade IV GVHD and died. The other 11 patients were still alive and event-free with a median follow-up duration of 455 days (range 84 approximately 715 days). CONCLUSION: An effective treatment for malignant hematological disease, G-CSF mobilized allogeneic bone marrow plus peripheral blood stem cells transplantation provides rapid and sustained engraftment without increase in incidence of aGVHD and cGVHD.
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Authors | Yuhong Chen, Xiaojun Huang, Lanping Xu, Daihong Liu, Yaochen Zhang, Hanyun Ren, Nailan Guo, Daopei Lu |
Journal | Zhonghua yi xue za zhi
(Zhonghua Yi Xue Za Zhi)
Vol. 82
Issue 19
Pg. 1306-9
(Oct 10 2002)
ISSN: 0376-2491 [Print] China |
PMID | 12509932
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Granulocyte Colony-Stimulating Factor
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Topics |
- Adolescent
- Adult
- Bone Marrow Transplantation
- Female
- Graft vs Host Disease
(prevention & control)
- Granulocyte Colony-Stimulating Factor
(pharmacology)
- Hematologic Neoplasms
(therapy)
- Hematopoietic Stem Cell Mobilization
(methods)
- Hematopoietic Stem Cell Transplantation
- Humans
- Male
- Middle Aged
- Pilot Projects
- Recurrence
- Transplantation, Homologous
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