[Olanzapine improves chorea in patients with Huntington's disease].

Abstract

INTRODUCTION:

The main treatment for choreatic movements associated to Huntington s disease are the neuroleptic drugs, however, its use causes long term troubles.

CASE REPORTS:

We describe two patients with a predominantly choreic Huntington s disease, who experience improvement of choreatic movements after introduction of olanzapine to their treatment, being this drug well tolerated.

CONCLUSIONS:

The improvement of chorea suggests that olanzapine has a dopaminergic D2 receptors blocking action.

• Authors: F J Jiménez-Jiménez, M de Toledo, I Puertas, M Barón, M Zurdo, B Barcenilla
• Journal: Revista de neurologia (Rev Neurol) 2002 Sep 16-30 Vol. 35 Issue 6 Pg. 524-5 ISSN: 0210-0010 [Print] Spain
• Vernacular Title: La olanzapina mejora el corea en pacientes con enfermedad de Huntington.
• PMID: 12389168 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Dopamine Antagonists
• Dopamine D2 Receptor Antagonists
• Serotonin Uptake Inhibitors
• Benzodiazepines
• Pirenzepine
• Olanzapine

Topics

• Benzodiazepines
• Chorea (drug therapy, etiology)
• Dopamine Antagonists (therapeutic use)
• Dopamine D2 Receptor Antagonists
• Humans
• Huntington Disease (complications, drug therapy)
• Male
• Middle Aged
• Olanzapine
• Pirenzepine (analogs & derivatives, therapeutic use)
• Selective Serotonin Reuptake Inhibitors (therapeutic use)