Long-term follow-up of globus pallidus chronic stimulation in advanced Parkinson's disease.

Abstract

To assess the long-term follow-up of the globus pallidus internus (GPi) stimulation, six patients were evaluated every year by using the Unified Parkinson's Disease Rating Scale (UPDRS). Three years postoperatively, GPi stimulation led to a significant improvement of dyskinesia severity (50%, P = 0.05) and activities of daily living (subscore of quality of life scale, 9%, P = 0.05). However, the improvement induced by chronic pallidal stimulation on the mean daily duration in the off state was lost at the last assessment.

• Authors: Franck Durif, Jean-Jacques Lemaire, Bérengère Debilly, Gérard Dordain
• Journal: Movement disorders : official journal of the Movement Disorder Society (Mov Disord) Vol. 17 Issue 4 Pg. 803-7 (Jul 2002) ISSN: 0885-3185 [Print] United States
• PMID: 12210880 (Publication Type: Journal Article)
• Copyright: Copyright 2002 Movement Disorder Society

Chemical References

• Antiparkinson Agents
• Levodopa

Topics

• Activities of Daily Living (classification)
• Aged
• Antiparkinson Agents (administration & dosage)
• Combined Modality Therapy
• Dominance, Cerebral (physiology)
• Electric Stimulation Therapy
• Electrodes, Implanted
• Female
• Follow-Up Studies
• Globus Pallidus (physiopathology)
• Humans
• Levodopa (administration & dosage)
• Male
• Middle Aged
• Motor Skills (physiology)
• Parkinson Disease (diagnosis, physiopathology, therapy)
• Quality of Life