HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Neuropsychologic outcome after bilateral pallidotomy in patients with Parkinson disease].

AbstractINTRODUCTION:
Although significant improvement of motor function following bilateral pallidotomy for the treatment of Parkinson's disease has been proved, the cognitive sequelae have not been clearly defined. There are recurrent loops interconnecting specific areas of the frontal cortex and the basal ganglia, suggesting the continuity or complementary functioning between these areas.
PATIENTS AND METHODS:
Pre- and postoperative cognitive function was evaluated in 19 Parkinsonian patients who underwent bilateral pallidotomy in order to clarify its effects on cognitive function. All patients were evaluated one day before the procedure and 12+ months after surgery using neuropsychological tests (Raven Progressive Matrices and Bergen Facial Recognition Test). Proper performance in these tests requires reasoning, abstraction and spatial memory, involving strongly the frontal functions. These functions could be described in terms of the "working memory" concept. Hand Mental Rotation Test was used as comparing task not involving frontal functions. Scores were analyzed by Student's t-test.
RESULTS:
Modest improvement was observed in these cognitive functions as assessed by Raven Progressive Matrices (p < 0.0688) and a significant change in the complex parts of Bergen Facial Recognition Test (p < 0.0547; p < 0.0468) was also noticed, but no change was registered in mental rotation tasks.
CONCLUSION:
Present data revealed that bilateral pallidotomy is associated with modest and long-lasting improvement in tasks involving the "working memory".
AuthorsPéter Kosztolányi, János Kállai, István Balás, Kázmér Karádi, Tamás Dóczi
JournalIdeggyogyaszati szemle (Ideggyogy Sz) Vol. 55 Issue 7-8 Pg. 263-7 (Jul 20 2002) ISSN: 0019-1442 [Print] Hungary
Vernacular TitleParkinson-kóros betegek neuropszichológiai teljesítményének változásai kétoldali pallidotomiát követóen.
PMID12201234 (Publication Type: English Abstract, Journal Article)
Topics
  • Age of Onset
  • Aged
  • Female
  • Globus Pallidus (surgery)
  • Humans
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Neurosurgical Procedures (methods)
  • Parkinson Disease (physiopathology, psychology, surgery)
  • Psychomotor Performance
  • Time Factors
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: