Effects of ABT-229, a motilin agonist, on acid reflux, oesophageal motility and gastric emptying in patients with gastro-oesophageal reflux disease.

Abstract

AIM:

The effect of ABT-229, a new macrolide with no antibacterial activity, on gastro-oesophageal reflux, oesophageal motility and gastric emptying in patients with gastro-oesophageal reflux disease was investigated.

METHODS:

Twenty-one patients were treated with a placebo and ABT-229 (2.5, 5 or 10 mg b.d.) in a randomized, incomplete crossover study design. Ambulatory 24-h pH manometry was performed and gastric emptying was assessed by the 13C-octanoic acid breath test on the seventh day of treatment.

RESULTS:

A significant decrease was found in the mean (+/- s.e.) percentage of reflux time (intra-oesophageal pH < 4) for ABT-229 5 mg b.d. and 10 mg b.d., but not for 2.5 mg b.d., compared with placebo. For ABT-229 5 mg, it was 8.5 +/- 0.5% vs. 10.7 +/- 0.7% (P < 0.038) and, for ABT-229 10 mg, it was 6.6 +/- 0.5% vs. 8.4 +/- 0.5% (P < 0.019). There were no significant differences in any of the analysed manometric parameters. In addition, the gastric half-emptying time for all doses of ABT-229 did not differ significantly from that after placebo.

CONCLUSIONS:

ABT-229 is able to reduce slightly, but significantly, acid reflux in patients with gastro-oesophageal reflux disease. This effect does not appear to be due to a measurable improvement in oesophageal motility or gastric emptying.

• Authors: P Netzer, B Schmitt, W Inauen
• Journal: Alimentary pharmacology & therapeutics (Aliment Pharmacol Ther) Vol. 16 Issue 8 Pg. 1481-90 (Aug 2002) ISSN: 0269-2813 [Print] England
• PMID: 12182748 (Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Gastrointestinal Agents
• Motilin
• Alemcinal
• Erythromycin

Topics

• Adult
• Aged
• Aged, 80 and over
• Cross-Over Studies
• Dose-Response Relationship, Drug
• Double-Blind Method
• Erythromycin (analogs & derivatives, therapeutic use)
• Female
• Gastric Emptying (drug effects)
• Gastroesophageal Reflux (drug therapy, physiopathology)
• Gastrointestinal Agents (therapeutic use)
• Gastrointestinal Motility (drug effects)
• Humans
• Hydrogen-Ion Concentration (drug effects)
• Male
• Manometry (methods)
• Middle Aged
• Motilin (agonists)