Abstract | BACKGROUND: METHODS: Plasma CRP by a modification of the laser nephelometry technique, IL-6 and serum albumin were determined in 103 chronic pre-dialytic patients (mean age 50 +/- 6.3 years; creatinine clearance (Cr.cl.) 36.3 +/- 23.1 ml/min). RESULTS: CRP was >5 mg/l (normal upper range) in 42% of the global population. CRP and IL-6 were significantly related (r = 0.35, p < 0.0004). CRP and IL-6 were related to renal function (CRP vs. Cr.cl., r = -0.56, p < 0.0001; IL-6 vs. Cr.cl., r = -0.55, p < 0.0001, Spearman correlation coefficient). When patients were divided in tertiles according to renal function, CRP median value resulted 7.9 mg/l (interquartile interval: 5-12) in the first tertile (Cr.cl. <18.5 ml/min), 4.0 mg/l (3-6) in the second tertile (Cr.cl. 18.5-45 ml/min) and 3.2 mg/l (2.7-4.0) in the last tertile (Cr.cl. >45 ml/min) (p < 0.0001). A negative correlation between CRP and S- albumin was also found (r = -0.52, p < 0.0001, Spearman correlation coefficient). CONCLUSIONS:
IL-6 and CRP were increased and were inversely related to creatinine clearance in our population of 103 chronic predialytic patients. The possibility of a decreased renal clearance of CRP and/or cytokines as a cause of an activated acute-phase response is discussed. A negative correlation between CRP and S- albumin was found confirming the link between chronic inflammation and malnutrition in chronic renal patients.
|
Authors | Vincenzo Panichi, Massimiliano Migliori, Stefano De Pietro, Daniele Taccola, Anna Maria Bianchi, Luca Giovannini, Maria Norpoth, Maria Rita Metelli, Renza Cristofani, Alberto A E Bertelli, Giulietta Sbragia, Ciro Tetta, Roberto Palla, R Colombo |
Journal | Nephron
(Nephron)
Vol. 91
Issue 4
Pg. 594-600
(Aug 2002)
ISSN: 1660-8151 [Print] Switzerland |
PMID | 12138260
(Publication Type: Journal Article)
|
Copyright | Copyright 2002 S. Karger AG, Basel |
Chemical References |
- Interleukin-6
- C-Reactive Protein
|
Topics |
- Adult
- C-Reactive Protein
(metabolism)
- Female
- Humans
- Interleukin-6
(blood)
- Kidney Failure, Chronic
(blood, physiopathology)
- Kidney Function Tests
- Male
- Middle Aged
- Nutritional Status
|