Abstract |
DM235 ( sunifiram), a new compound structurally related to piracetam, prevented the amnesia induced by scopolamine (1.5 mg kg(-1) i.p.), after intraperitoneal (0.001-0.1 mg kg(-1)) or oral (0.01-0.1 mg kg(-1)) administration, as shown by a passive avoidance test in mice. The antiamnesic effect of DM235 was comparable to that of well-known nootropic drugs such as piracetam (30-100 mg kg(-1) i.p.), aniracetam (100 mg kg(-1) p.o.) or rolipram (30 mg kg(-1) p.o.). DM235 also prevented mecamylamine (20 mg kg(-1) i.p.)-, baclofen (2 mg kg(-1) i.p.)- and clonidine (0.125 mg kg(-1) i.p.)-induced amnesia in the same test. In the Morris water maze test with rats, scopolamine (0.8 mg kg(-1) i.p.) inhibited the reduction of escape latency in both acquisition and retention/retraining tests. DM235 (0.1 mg kg(-1) i.p.), 20 min before each daily acquisition training, prevented the scopolamine-induced memory impairment. DM235 (1 mg kg(-1) i.p.) also reduced the duration of pentobarbitone-induced hypnosis in mice without modifying the induction time of hypnosis. At the highest effective doses, the investigated compound neither impaired motor coordination (rota-rod test), nor modified spontaneous motility and inspection activity (Animex and hole board tests). These results indicate that DM235, a compound structurally related to piracetam, is a novel nootropic endowed with the capability to prevent cognitive deficits at very low doses. Indeed, its potency is about 1,000 times higher than that of the most active piracetam-like compounds.
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Authors | C Ghelardini, N Galeotti, F Gualtieri, M N Romanelli, C Bucherelli, E Baldi, A Bartolini |
Journal | Naunyn-Schmiedeberg's archives of pharmacology
(Naunyn Schmiedebergs Arch Pharmacol)
Vol. 365
Issue 6
Pg. 419-26
(Jun 2002)
ISSN: 0028-1298 [Print] Germany |
PMID | 12070754
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Nootropic Agents
- Piperazines
- DM 235
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Topics |
- Animals
- Avoidance Learning
(drug effects, physiology)
- Cognition
(drug effects, physiology)
- Dose-Response Relationship, Drug
- Male
- Maze Learning
(drug effects, physiology)
- Mice
- Nootropic Agents
(chemistry, pharmacology)
- Piperazines
(chemistry, pharmacology)
- Rats
- Rats, Long-Evans
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