[Efficacy and safety of polaprezinc as a preventive drug for radiation-induced stomatitis].

Abstract

BACKGROUND:

Radiation-induced stomatitis is one of the adverse effects of total body irradiation(TBI). We examined the usefulness of oral polaprezinc as a preventive drug for stomatitis.

PATIENTS AND METHODS:

The present study was conducted with 19 patients who were diagnosed with hematologic malignancy and who underwent TBI as pretreatment for bone marrow transplantation, peripheral blood stem transplantation, or cord blood stem cell transplantation. Eleven patients ingested the suspension of polaprezinc and 2% carmellose sodium (carboxymethylcellulose sodium: CMC) beginning the day before TBI(P-CMC group), while the other eight patients did not ingest P-CMC(control group). The severity of stomatitis was assessed in each group during a four-weeks period.

RESULTS:

Stomatitis (Grade: > or = 3) developed in one of 11 patients in the polaprezinc group and in 4 of 8 patients in the control group(P = 0.046). The times at which stomatitis development ranged between weeks 1 and 2 after the onset of TBI in the two groups. No adverse reaction owing to the ingestion of P-CMC was observed.

CONCLUSIONS:

These results suggested the efficacy and safety of polaprezinc as a preventive drug for radiation-induced stomatitis.

• Authors: Fujiwara Masayuki, Kamikonya Norihiko, Tsuboi Keita, Irie Miwa, Izumi Masayuki, Irie Toshihiko, Fujisawa Hiromi, Muro Chikaaki, Nakao Norio
• Journal: Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica (Nihon Igaku Hoshasen Gakkai Zasshi) Vol. 62 Issue 4 Pg. 144-50 (Mar 2002) ISSN: 0048-0428 [Print] Japan
• PMID: 12043217 (Publication Type: Journal Article)

Chemical References

• Anti-Ulcer Agents
• Organometallic Compounds
• Zinc Compounds
• polaprezinc
• Carnosine

Topics

• Adult
• Anti-Ulcer Agents (therapeutic use)
• Carnosine (analogs & derivatives, therapeutic use)
• Female
• Humans
• Male
• Organometallic Compounds (therapeutic use)
• Radiation Injuries (prevention & control)
• Stomatitis (prevention & control)
• Whole-Body Irradiation (adverse effects)
• Zinc Compounds