Safety and efficacy of transjugular intrahepatic portosystemic shunt creation for the treatment of hepatic hydrothorax.

Abstract

PURPOSE:

To evaluate safety and efficacy of transjugular intrahepatic portosystemic shunt (TIPS) creation for hepatic hydrothorax (HHyd).

MATERIALS AND METHODS:

Twenty-one patients underwent TIPS creation for HHyd. A prospective TIPS database and medical records were reviewed. Clinical and radiographic outcomes were recorded as complete (symptom/effusion resolution), partial (improved symptoms/effusion), or none. Data patterns were examined with chi(2) tests and Kaplan-Meier analysis.

RESULTS:

Patients included 12 women and nine men, with a mean age of 56 years, all with Child class B (n = 7) or C (n = 14) disease. The technical success rate was 100%. Mean follow-up was 223 days. Twenty-nine percent (six of 21) died within 30 days of TIPS creation, 10% (two of 21) underwent transplantation within 30 days, and 62% (13 of 21) survived beyond 30 days. Data were incomplete in two patients. Clinical response was classified as complete in 63% (12 of 19), partial in 11% (two of 19), and none in 26% (five of 19). Radiographic response was classified as complete in 30% (six of 20), partial in 50% (10 of 20), and none in 20% (four of 20). Nonresponders had multisystem organ failure, and all but one died within 30 days. However, of the 13 patients surviving longer than 30 days, 10 (77%) had a complete clinical response.

CONCLUSION:

TIPS is a relatively safe and effective method of controlling HHyd. The majority of patients experienced improvement or resolution of clinical symptoms with a variable reduction in the quantity of pleural fluid. There was a tendency among nonresponders to die within 30 days.

• Authors: E Brooke Spencer, Daniel T Cohen, Michael D Darcy
• Journal: Journal of vascular and interventional radiology : JVIR (J Vasc Interv Radiol) Vol. 13 Issue 4 Pg. 385-90 (Apr 2002) ISSN: 1051-0443 [Print] United States
• PMID: 11932369 (Publication Type: Comparative Study, Evaluation Study, Journal Article)

Topics

• Adult
• Aged
• Female
• Humans
• Hydrothorax (etiology, mortality, therapy)
• Hypertension, Portal (complications)
• Liver Diseases (complications)
• Liver Transplantation
• Male
• Middle Aged
• Portasystemic Shunt, Transjugular Intrahepatic (adverse effects, mortality)
• Severity of Illness Index
• Survival Analysis
• Treatment Outcome