Bullous lesions in Bazex syndrome and successful treatment with oral psoralen phototherapy.

Abstract

A 59-year-old man presented with a psoriasiform dermatitis with associated bullae and destructive nail dystrophy of the hands and feet. He had lost 10 kg weight over 6 months and a mass in the neck was noted. He was provisionally diagnosed with Bazex syndrome (acrokeratosis paraneoplastica) and subsequent investigations revealed a squamous cell carcinoma in the right piriform fossa. His skin lesions were treated with oral psoralen and ultraviolet A phototherapy and this cleared the cutaneous changes, but the nail changes have persisted at 18 months follow up.

• Authors: D Gill, P Fergin, J Kelly
• Journal: The Australasian journal of dermatology (Australas J Dermatol) Vol. 42 Issue 4 Pg. 278-80 (Nov 2001) ISSN: 0004-8380 [Print] Australia
• PMID: 11903162 (Publication Type: Case Reports, Journal Article)

Chemical References

• Photosensitizing Agents
• Ficusin

Topics

• Acrodermatitis (pathology, therapy)
• Administration, Oral
• Biopsy
• Carcinoma, Squamous Cell (complications, pathology, therapy)
• Ficusin (therapeutic use)
• Head and Neck Neoplasms (complications, pathology, therapy)
• Humans
• Keratosis (pathology, therapy)
• Male
• Middle Aged
• PUVA Therapy (methods)
• Paraneoplastic Syndromes (complications, pathology, therapy)
• Photosensitizing Agents (therapeutic use)