The efficacy of chondroitin sulfate 0.2% in treating interstitial cystitis.

Abstract

OBJECTIVE:

An open label study of chondroitin sulfate was undertaken to determine the response of patients with interstitial cystitis and positive potassium test results to this agent.

METHOD:

Eighteen patients with classic features of interstitial cystitis were enrolled in the study. Patients received 40 mL chondroitin sulfate, 0.2% instilled intravesically once a week for four weeks and then once a month for 12 months. At the same times, Quality of Life Improvement scores, voiding diaries, and pain and voiding indices were reviewed.

RESULTS:

Thirteen of 18 patients were followed for the entire 13-month study. Twelve of these patients responded to treatment within 3 to 12 weeks, on average. A total of 6/13 (46.2%) showed a good response, 2/13 (15.4%) had a fair response, and 4/13 (30.8%) had a partial response and 1/13 (7.7%) showed no response.

CONCLUSION:

Intravesical chondroitin sulfate seems to demonstrate some beneficial effects in treatment of interstitial cystitis patients who have positive potassium stimulation test results.

• Authors: G Steinhoff, B Ittah, S Rowan
• Journal: The Canadian journal of urology (Can J Urol) Vol. 9 Issue 1 Pg. 1454-8 (Feb 2002) ISSN: 1195-9479 [Print] Canada
• PMID: 11886599 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Chondroitin Sulfates

Topics

• Chondroitin Sulfates (administration & dosage)
• Cystitis, Interstitial (drug therapy)
• Female
• Humans
• Male