Abstract | BACKGROUND: CASE REPORT: We report a single case study of a 29-year-old male patient with APMPPE. Approximately four months after diagnosis of APMPPE the patient developed a temporary tetraparesis as initial symptom of chronic inflammatory cerebral disease. We give an overview of the stated theories of the pathogenesis of APMPPE in the literature. Moreover we account on concomitant systemic symptoms and diseases. We outline neurological complications in APMPPE and discuss the reported therapies. RESULTS: Neurological complications rarely accompany APMPPE and may occur even months after the initial ocular symptoms. There have been reports of meningoencephalitis and cerebral vasculitis and two patients died of neurological complications. The recommended therapeutic regime is high-dose corticosteroids. Relapses can appear during tapering of systemic corticosteroids therapy. The role of immunsuppressive treatment remains unclear. CONCLUSION:
APMPPE can be associated with serious inflammatory systemic and neurological affection. Instruction of the patient is indispensable to guarantee early and adequate treatment.
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Authors | E K Reinthal, T Schlote, M Zierhut |
Journal | Klinische Monatsblatter fur Augenheilkunde
(Klin Monbl Augenheilkd)
Vol. 218
Issue 12
Pg. 756-62
(Dec 2001)
ISSN: 0023-2165 [Print] Germany |
Vernacular Title | Neurologische Komplikationen bei akuter posteriorer multifokaler plakoider Pigmentepitheliopathie (APMPPE) - eine Literaturübersicht mit Kasuistik1. |
PMID | 11805866
(Publication Type: Case Reports, English Abstract, Journal Article)
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Topics |
- Acute Disease
- Adult
- Chorioretinitis
(diagnosis, etiology)
- Humans
- Male
- Neurologic Examination
- Patient Care Team
- Pigment Epithelium of Eye
- Quadriplegia
(diagnosis, etiology)
- Vasculitis, Central Nervous System
(diagnosis, etiology)
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