Abstract | INTRODUCTION: METHODS: All patients with symptoms of chronic anal fissure were randomly assigned to one of two treatment arms. The glyceryl trinitrate group applied 0.2 percent paste to the perianal area three times a day for eight weeks. Patients in the lateral sphincterotomy group underwent surgery on the next available operating list. Patients were reviewed at two weekly intervals until the fissure healed. RESULTS: CONCLUSION:
Glyceryl trinitrate paste heals the majority of chronic anal fissures. However, a significant minority have little improvement or develop side effects and require conventional surgical treatment. Poor compliance with prescribed treatment often contributes to nonhealing. In addition, some fissures which initially heal with glyceryl trinitrate paste recur and require further treatment. Glyceryl trinitrate treatment is labor intensive for patients and physicians and has not been shown to be superior to lateral sphincterotomy.
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Authors | J Evans, A Luck, P Hewett |
Journal | Diseases of the colon and rectum
(Dis Colon Rectum)
Vol. 44
Issue 1
Pg. 93-7
(Jan 2001)
ISSN: 0012-3706 [Print] United States |
PMID | 11805569
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Vasodilator Agents
- Nitroglycerin
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Topics |
- Administration, Topical
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Anal Canal
(drug effects, surgery)
- Chronic Disease
- Female
- Fissure in Ano
(drug therapy, surgery)
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Nitroglycerin
(administration & dosage, therapeutic use)
- Patient Compliance
- Prospective Studies
- Recurrence
- Time Factors
- Treatment Outcome
- Vasodilator Agents
(administration & dosage, therapeutic use)
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