The behavioral pharmacology of butaclamol hydrochloride (AY-23,028), a new potent neuroleptic drug.

Abstract

Butaclamol hydrochloride (AY-23,028) is a member of a new chemical class for which antipsychotic activity in humans has recently been demonstrated. The compound antagonized amphetamine-induced stereotyped behavior in rats, amphetamine toxicity in aggregated mice and apomorphine-induced emesis in dogs. It depressed both discriminated avoidance and continuous lever-pressing behavior in rats and inhibited ambulation and rearing in the open field. At higher doses, AY-23,028 induced catalepsy. Adrenergic blocking activity, measured by the antagonism of epinephrine-induced mortality, was weak. These pharmacological actions are characteristic of neuroleptic drugs. In the dose range where the aforementioned effects were observed AY-23,028 did not antagonize either the tetrabenazine-induced ptosis or the tremorine syndrome and did not cause either hypothermia or ataxia. The potency and onset of action of AY-23,028 were comparable to those of fluphenazine but AY-23,028 was of longer duration. The results are discussed in relation to current concepts of neuroleptic mechanisms.

• Authors: K Voith, F Herr
• Journal: Psychopharmacologia (Psychopharmacologia) Vol. 42 Issue 1 Pg. 11-20 (Apr 30 1975) Germany
• PMID: 1171496 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Dibenzocycloheptenes
• Quinolizines
• Tranquilizing Agents
• Amphetamine
• Apomorphine
• Fluphenazine
• Dextroamphetamine
• Chlorpromazine
• Epinephrine

Topics

• Amphetamine (toxicity)
• Animals
• Apomorphine (antagonists & inhibitors)
• Avoidance Learning (drug effects)
• Behavior, Animal (drug effects)
• Catalepsy (chemically induced)
• Chlorpromazine (pharmacology)
• Dextroamphetamine (antagonists & inhibitors)
• Dibenzocycloheptenes (pharmacology)
• Discrimination Learning (drug effects)
• Dogs
• Epinephrine (antagonists & inhibitors, toxicity)
• Fluphenazine (pharmacology)
• Humans
• Male
• Mice
• Motor Activity (drug effects)
• Quinolizines (pharmacology)
• Rats
• Stereotyped Behavior (drug effects)
• Tranquilizing Agents (pharmacology)
• Vomiting (chemically induced, drug therapy)