Treatment of Absidia corymbifera infection in mice with amphotericin B and itraconazole.

Abstract

The activities of amphotericin B and itraconazole were studied in a temporarily neutropenic murine model of disseminated Absidia corymbifera infection, caused by two different strains. Amphotericin B MICs were 0.25 mg/L for both strains and itraconazole MICs were 1 and 2 mg/L. Amphotericin B was effective in vivo with both isolates. Itraconazole was less effective.

• Authors: J Mosquera, P A Warn, J L Rodriguez-Tudela, D W Denning
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 48 Issue 4 Pg. 583-6 (Oct 2001) ISSN: 0305-7453 [Print] England
• PMID: 11581243 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antifungal Agents
• Itraconazole
• Amphotericin B

Topics

• Absidia (classification, drug effects)
• Amphotericin B (therapeutic use)
• Animals
• Antifungal Agents (therapeutic use)
• Disease Models, Animal
• Humans
• Itraconazole (therapeutic use)
• Male
• Mice
• Microbial Sensitivity Tests (methods)
• Mucormycosis (drug therapy, microbiology)