Abstract |
Intravenously administered carrier-free 67Cu appeared rapidly in the bile of rats with a recently created biliary fistula; maximal excretion occurred within the first 2 hours. However, if the biliary fistula had been created 3 or 4 days before injection of the 67Cu, only one-fourth to one-half as much of the isotope appeared in the bile. There also was a small decrease in stable biliary copper. When rats with biliary fistula were compared with rats with permanent biliary obstruction, over a period of 6 weeks, both exhibited a marked increase in plasma copper and an equally pronounced increase in the rho-phenylenediamine oxidase activity of plasma but no increase in hepatic copper. Peaks in blood were reached within 2 weeks and then slowly diminished. Sham-operated rats had parallel, but much lower, copper and enzyme changes. Correlations between these rat studies and the copper retention of Wilson's disease and of primary biliary cirrhosis are suggested.
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Authors | C A Owen |
Journal | Mayo Clinic proceedings
(Mayo Clin Proc)
Vol. 50
Issue 7
Pg. 412-5
(Jul 1975)
ISSN: 0025-6196 [Print] England |
PMID | 1152534
(Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
|
Topics |
- Animals
- Bile
(metabolism)
- Biliary Fistula
(metabolism)
- Biliary Tract Diseases
(metabolism)
- Copper
(metabolism)
- Liver
(metabolism)
- Male
- Perfusion
- Radioisotopes
- Rats
- Stress, Physiological
(metabolism)
- Time Factors
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