Proton magnetic resonance spectroscopy of brain metabolites in galactosemia.

Abstract

Brain edema may occur in infants with galactosemia and has been associated with accumulation of galactitol. Proton magnetic resonance spectra were obtained from 12 patients (four newly diagnosed neonates and eight patients on galactose-restricted diets, age range 1.7-47 years) and control subjects to measure brain galactitol levels in vivo and correlate them with urinary galactitol excretion. The results demonstrate that a markedly elevated brain galactitol level may be present only in newborn infants with galactosemia who exhibit massive urinary galactitol excretion.

• Authors: Z J Wang, G T Berry, S F Dreha, H Zhao, S Segal, R A Zimmerman
• Journal: Annals of neurology (Ann Neurol) Vol. 50 Issue 2 Pg. 266-9 (Aug 2001) ISSN: 0364-5134 [Print] United States
• PMID: 11506413 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Protons

Topics

• Adolescent
• Adult
• Brain (metabolism)
• Child
• Female
• Galactosemias (metabolism)
• Humans
• Infant
• Infant, Newborn
• Magnetic Resonance Spectroscopy
• Male
• Middle Aged
• Protons