Abstract | BACKGROUND/AIM: METHODS: Products were applied on the back skin 60 min and 5 min before and 5 min after UVL irradiation. Untreated test sites served as controls. Clinical evaluation, measurements of epidermal hydration (Corneometer) and mechanical properties of the skin (Cutometer) were made 1 h before and 24 h after exposure. RESULTS: Test areas treated with indomethacin 60 min and 5 min before irradiation showed the significantly lowest visual erythema scores and no significant changes in skin mechanical parameters. At all other test sites, a significant decrease in elasticity parameters (Ue, Ur, Ua/Uf, Ur/Uf) and an increase in viscoelasticity parameters (Uv, Uv/Ue) of the skin were observed. No significant changes of epidermal hydration were found at any of the test sites. CONCLUSION: The inhibitory action of topical indomethacin on UVL-induced inflammation is superior to beta-methasone valerate and emollients. Non-invasive measurement of skin elasticity could be used as a supplementary tool for objective evaluation and comparison of the photoprotective activity of different topical agents.
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Authors | H Dobrev |
Journal | Photodermatology, photoimmunology & photomedicine
(Photodermatol Photoimmunol Photomed)
Vol. 17
Issue 4
Pg. 184-8
(Aug 2001)
ISSN: 0905-4383 [Print] England |
PMID | 11499541
(Publication Type: Journal Article)
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Chemical References |
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Emollients
- Betamethasone
- Indomethacin
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Topics |
- Administration, Topical
- Adult
- Anti-Inflammatory Agents
(therapeutic use)
- Anti-Inflammatory Agents, Non-Steroidal
(therapeutic use)
- Betamethasone
(therapeutic use)
- Elasticity
(drug effects, radiation effects)
- Emollients
(therapeutic use)
- Erythema
(drug therapy, etiology, prevention & control)
- Female
- Humans
- Indomethacin
(therapeutic use)
- Male
- Skin
(drug effects, radiation effects)
- Ultraviolet Rays
(adverse effects)
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