[Antigenicity and phototoxicity of water-soluble extract from Salacia reticulata (Celastraceae)].

Abstract

The antigenicity and phototoxicity of water-soluble extract from Salacia reticulata (SRE) were examined in guinea pigs. In a study of active systemic anaphylaxis reaction, neither the oral administration group (64 or 320 mg/kg, 5 times/week, 3 weeks) nor the subcutaneous administration group (64 mg/kg, 1 time/week, 3 weeks) exhibited any anaphylactic reaction. Moreover, sensitization with serum obtained from these animals did not induce passive cutaneous anaphylaxis reaction in normal animals. In a phototoxicity study, oral administration of SRE (320 mg/kg) induced neither erythema nor edema. These results suggest that SRE is not antigenic or phototoxic.

• Authors: H Shimoda, I Asano, Y Yamada
• Journal: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan (Shokuhin Eiseigaku Zasshi) Vol. 42 Issue 2 Pg. 144-7 (Apr 2001) ISSN: 0015-6426 [Print] Japan
• PMID: 11486382 (Publication Type: English Abstract, Journal Article)

Chemical References

• Epitopes
• Plant Extracts
• Water

Topics

• Anaphylaxis (immunology)
• Animals
• Dermatitis, Phototoxic (immunology)
• Epitopes
• Guinea Pigs
• Male
• Plant Extracts (immunology, toxicity)
• Plants, Medicinal (chemistry)
• Rosales (metabolism)
• Solubility
• Water