Abstract |
The Caenorhabditis elegans excretory cell extends tubular processes, called canals, along the basolateral surface of the epidermis. Mutations in the exc-5 gene cause tubulocystic defects in this canal. Ultrastructural analysis suggests that exc-5 is required for the proper placement of cytoskeletal elements at the apical epithelial surface. exc-5 encodes a protein homologous to guanine nucleotide exchange factors and contains motif architecture similar to that of FGD1, which is responsible for faciogenital dysplasia. exc-5 interacts genetically with mig-2, which encodes Rho GTPase. These results suggest that EXC-5 controls the structural organization of the excretory canal by regulating Rho family GTPase activities.
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Authors | N Suzuki, M Buechner, K Nishiwaki, D H Hall, H Nakanishi, Y Takai, N Hisamoto, K Matsumoto |
Journal | EMBO reports
(EMBO Rep)
Vol. 2
Issue 6
Pg. 530-5
(Jun 2001)
ISSN: 1469-221X [Print] England |
PMID | 11415987
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Caenorhabditis elegans Proteins
- DNA, Complementary
- Guanine Nucleotide Exchange Factors
- Helminth Proteins
- exc-5 protein, C elegans
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Topics |
- Amino Acid Sequence
- Animals
- Animals, Genetically Modified
- Caenorhabditis elegans
(chemistry, embryology, ultrastructure)
- Caenorhabditis elegans Proteins
- Chromosome Mapping
- DNA, Complementary
(metabolism)
- Exons
- Guanine Nucleotide Exchange Factors
(genetics, physiology)
- Helminth Proteins
(genetics, physiology)
- Introns
- Microscopy, Electron
- Models, Genetic
- Molecular Sequence Data
- Mutation
- Plasmids
(metabolism)
- Protein Binding
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