Abstract | BACKGROUND: OBJECTIVE: PATIENTS AND METHODS: A single-blind double-dummy placebo-controlled crossover study was performed comparing once daily 10 mg oral montelukast with 400 microg inhaled plus 200 microg intranasal budesonide in 12 patients with allergic rhinitis and asthma: mean (S.E.) age 34.0 years (2.7), forced expiratory volume in 1 s (FEV1) 91.2 (3.8)% predicted. Each treatment was for 2 weeks with a 1-week placebo run-in and washout. Measurements were made after each active treatment and placebo for: adenosine monophosphate bronchial challenge, exhaled and nasal nitric oxide. Patients also recorded their domiciliary peak expiratory flow, nasal peak inspiratory flow, asthma and seasonal allergic rhinitis symptoms. RESULTS: CONCLUSION: Once-daily inhaled plus intranasal budesonide and once daily montelukast showed comparable efficacy on lower airway, but only the budesonide had significant efficacy on upper airway inflammatory markers. Both treatments significantly reduced allergic rhinitis symptoms.
|
Authors | A M Wilson, O J Dempsey, E J Sims, B J Lipworth |
Journal | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
(Clin Exp Allergy)
Vol. 31
Issue 4
Pg. 616-24
(Apr 2001)
ISSN: 0954-7894 [Print] England |
PMID | 11359431
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Acetates
- Anti-Asthmatic Agents
- Anti-Inflammatory Agents
- Biomarkers
- Cyclopropanes
- Quinolines
- Sulfides
- Budesonide
- montelukast
|
Topics |
- Acetates
(administration & dosage, therapeutic use)
- Administration, Oral
- Administration, Topical
- Adult
- Anti-Asthmatic Agents
(therapeutic use)
- Anti-Inflammatory Agents
(therapeutic use)
- Asthma
(drug therapy)
- Biomarkers
- Budesonide
(administration & dosage, therapeutic use)
- Confidence Intervals
- Cross-Over Studies
- Cyclopropanes
- Humans
- Quinolines
(administration & dosage, therapeutic use)
- Rhinitis, Allergic, Seasonal
(drug therapy)
- Single-Blind Method
- Sulfides
|