We report two patients with
Churg-Strauss syndrome (CSS) which occurred on the remission stage of
bronchial asthma. Case 1 of a 64-year-old woman suffered from
asthma in June, 1997, and got relief with treatment. In February, 1998,
dysesthesia,
pain and severe
muscle weakness occurred in the extremities and erythematous rashes appeared on the extremities and back. She was transferred to our hospital on March 3. Peripheral blood
eosinophilia was observed and a diagnosis of CSS was made. Eosinophilic tissue infiltration and
vasculitis was found in the skin biopsy specimen. She was treated with
prednisolone (60 mg/day) with moderate improvement. But the
dysesthesia in the extremities, bilateral
foot drop and the weakness of the left hand grasping power continued. Case 2 of a 62-year-old woman suffered from
asthma in 1995, which improved by treatment. In March 1998,
dysesthesia and
pain in the lower extremities occurred and progressed. Erythematous rashes appeared on the feet and she was admitted to our hospital in May. Peripheral blood
eosinophilia and eosinophilic tissue infiltration in the skin biopsy specimen were observed and a diagnosis of CSS was made. The treatment with
prednisolone (60 mg/day) improved the
pain but the
dysesthesia continued. It is important to know the occurrence of CSS on the remission stage of
bronchial asthma.