The experimental animal models for assessing treatment of restenosis.

Abstract

Coronary restenosis after percutaneous interventions remains a major clinical problem. The assessment of therapies for the prevention of restenosis relies on the use of experimental models. This review describes the most frequently used animal models of coronary artery retenosis and the intraspecies differences among them, particularly in the extent and composition of the neointimal thickening. These differences in neointima formation should be considered in the interpretation of effective antiproliferative therapies before they are transferred into clinical trials.

• Authors: B Kantor, K Ashai, D R Holmes Jr, R S Schwartz
• Journal: Cardiovascular radiation medicine (Cardiovasc Radiat Med) 1999 Jan-Mar Vol. 1 Issue 1 Pg. 48-54 ISSN: 1522-1865 [Print] United States
• PMID: 11272356 (Publication Type: Comparative Study, Journal Article, Review)

Topics

• Animals
• Coronary Disease (etiology, pathology, therapy)
• Disease Models, Animal
• Dogs
• Humans
• Muscle, Smooth, Vascular (pathology)
• Rabbits
• Rats
• Recurrence
• Species Specificity
• Swine