[Nonpreserved topical steroids and lacrimal punctal occlusion for severe keratoconjunctivitis sicca].

Abstract

PURPOSE:

To analyze the efficacy of topical nonpreserved steroids before punctal occlusion in the treatment of severe keratoconjunctivitis sicca associated with Sjögren's syndrome.

METHODS:

We performed a prospective study including 15 patients, 30 eyes, (group 1) treated with topical nonpreserved steroids for 2 weeks and then punctal occlusion, and 15 patients, 30 eyes, (group 2) treated directly with punctal occlusion. Symptom severity (0-3+) and corneal fluorescein staining (0-9+) were evaluated after a week and after two months, and results were statistically compared between both groups with the t Student test.

RESULTS:

Symptom severity was negative in 67% of patients of group 1 and in 27% of patients of group 2 (p=0.0001 ) after a week, and in 80% of patients in group 1 and in 33% of patients of group 2 (p=0.0003) after 2 months. Corneal fluorescein staining was negative in 67% (OD) and 73% (OI) of patients of group 1 and in 33% (AO) of patients of group 2 (p=0.0001, AO) after a week, and in 80% (AO) of patients of group 1 and in 60% of patients of group 2 (AO) (p=0.0001, AO) after 2 months. There were no patients with side effects or complications.

CONCLUSIONS:

Topical nonpreserved steroid therapy for two weeks before punctal occlusion is effective in controlling symptoms and corneal fluorescein staining in patients with severe keratoconjunctivitis sicca associated with Sjögren's syndrome.

• Authors: Sainz De La Maza Serra M, Simón Castellvi C, O Kabbani
• Journal: Archivos de la Sociedad Espanola de Oftalmologia (Arch Soc Esp Oftalmol) Vol. 75 Issue 11 Pg. 751-756 (Nov 2000) ISSN: 0365-6691 [Print] Spain
• Vernacular Title: Esteroides tópicos sin conservantes y oclusión de los puntos lagrimales para la queratoconjuntivitis sicca grave.
• PMID: 11151264 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Inflammatory Agents
• Glucocorticoids

Topics

• Administration, Topical
• Adult
• Aged
• Anti-Inflammatory Agents (therapeutic use)
• Female
• Glucocorticoids
• Humans
• Keratoconjunctivitis Sicca (therapy)
• Lacrimal Apparatus
• Male
• Middle Aged
• Prospective Studies
• Prostheses and Implants
• Severity of Illness Index
• Sjogren's Syndrome