Abstract | OBJECTIVE: STUDY DESIGN: RESULTS: (1) TNF-R1 and TNF-R2 were detectable in all samples, and their concentrations decreased with advancing gestational age (r = -0.8 and r = -0.7; P<.0001 and P<.001, respectively). (2) The mean fetal plasma concentrations of TNF-R1 and TNF-R2 were significantly higher in fetuses with fetal inflammatory response syndrome than in those without the syndrome after adjustment for gestational age and fetal membrane status (TNF-R1: no fetal inflammatory response syndrome, mean +/- SE, 3473.7+/-128.8 pg/mL; vs fetal inflammatory response syndrome, mean +/- SE, 4079.9+/-190.7 pg/mL; P<.005; TNF-R2: no fetal inflammatory response syndrome, mean +/- SE, 6033.2+/-235.4 pg/mL; vs. fetal inflammatory response syndrome, mean +/- SE, 7783.1+/-342.8 pg/mL; P<.0001). (3) Fetuses of patients who delivered within 72 hours of cordocentesis had significantly higher concentrations of TNF-R1 and TNF-R2 receptors than those with longer latency periods (P<.05 for each). CONCLUSION:
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Authors | R Romero, E Maymon, P Pacora, R Gomez, M Mazor, B H Yoon, S M Berry |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 183
Issue 5
Pg. 1070-7
(Nov 2000)
ISSN: 0002-9378 [Print] United States |
PMID | 11084543
(Publication Type: Journal Article)
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Chemical References |
- Antigens, CD
- Receptors, Tumor Necrosis Factor
- Receptors, Tumor Necrosis Factor, Type I
- Receptors, Tumor Necrosis Factor, Type II
- Tumor Necrosis Factor-alpha
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Topics |
- Adult
- Antigens, CD
(blood, physiology)
- Female
- Fetal Blood
- Fetal Diseases
(blood, physiopathology)
- Homeostasis
- Humans
- Inflammation
(blood, physiopathology)
- Pregnancy
- Receptors, Tumor Necrosis Factor
(blood, physiology)
- Receptors, Tumor Necrosis Factor, Type I
- Receptors, Tumor Necrosis Factor, Type II
- Reference Values
- Solubility
- Tumor Necrosis Factor-alpha
(metabolism)
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