Abstract | PURPOSE: METHODS: RESULTS: After 1 week on maintenance treatment, seizures were completely controlled, but the child developed hypoactivity, decreased reactivity, and affective detachment. An EEG recording revealed subcontinuous sharp-wave discharges with irregular runs of atypical spike-wave complexes over the anterior regions of both hemispheres, consistent with a diagnosis of frontal NCSE. A reduction in tiagabine dosage to 15 mg/day led to complete regression of the behavioral and affective changes and to disappearance of the subcontinuous EEG discharges. CONCLUSIONS: Although tiagabine-induced NCSE has been described previously, particularly in patients with preexisting spike-wave abnormalities, this is the first report that identifies its potential role in the precipitation of frontal NCSE.
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Authors | P Piccinelli, R Borgatti, E Perucca, A Tofani, G Donati, U Balottin |
Journal | Epilepsia
(Epilepsia)
Vol. 41
Issue 11
Pg. 1485-8
(Nov 2000)
ISSN: 0013-9580 [Print] United States |
PMID | 11077464
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Anticonvulsants
- Nipecotic Acids
- Tiagabine
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Topics |
- Anticonvulsants
(adverse effects, therapeutic use)
- Brain
(abnormalities)
- Child
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Electroencephalography
(statistics & numerical data)
- Epilepsies, Partial
(drug therapy)
- Epilepsy, Frontal Lobe
(chemically induced, diagnosis)
- Humans
- Male
- Nipecotic Acids
(adverse effects, therapeutic use)
- Status Epilepticus
(chemically induced, diagnosis)
- Tiagabine
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