alpha-Methylnoradrenaline induced hypotension and bradycardia after administration into the area of the nucleus tractus solitarii.

Abstract

Bilateral injections of alpha-methylnoradrenaline into the area of the nucleus tractus solitarii of the brain stem caused a dose-dependent decrease of systemic arterial blood pressure and heart rate of anesthetized rats. The effects were prevented and even reversed by a preceding injection of the alpha-adrenoceptor blocking agent phentolamine. Pressor doses of angiotensin II and of arginine-vasopressin at the same site failed to drcrease blood pressure and heart rate.

• Authors: F P Nijkamp, W De Jong
• Journal: European journal of pharmacology (Eur J Pharmacol) 1975 Jun-Jul Vol. 32 Issue 02 Pg. 361-4 ISSN: 0014-2999 [Print] Netherlands
• PMID: 1097260 (Publication Type: Journal Article)

Chemical References

• Angiotensin II
• Arginine Vasopressin
• Nordefrin
• Norepinephrine
• Phentolamine

Topics

• Angiotensin II (pharmacology)
• Animals
• Arginine Vasopressin (pharmacology)
• Blood Pressure (drug effects)
• Depression, Chemical
• Heart Rate (drug effects)
• Male
• Medulla Oblongata
• Nervous System Physiological Phenomena
• Neural Pathways (physiology)
• Nordefrin (pharmacology)
• Norepinephrine (analogs & derivatives)
• Phentolamine (pharmacology)
• Rats
• Time Factors