Cytotoxic triterpene acids from the Peruvian medicinal plant Polylepis racemosa.

Abstract

Cytotoxicity-guided fractionation of the bark and stem extract of Polylepis racemosa led to the identification of ursolic acid, pomolic acid, 3-O-acetylpomolic acid, and 2-oxopomolic acid. Pomolic acid was the most cytotoxic component, and was specific for M-14 melanoma and ME180 cervical carcinoma, with GI50 values of 6.9 and 8.3 micrograms/mL respectively.

• Authors: C C Neto, A J Vaisberg, B N Zhou, D G Kingston, G B Hammond
• Journal: Planta medica (Planta Med) Vol. 66 Issue 5 Pg. 483-4 (Jun 2000) ISSN: 0032-0943 [Print] Germany
• PMID: 10909276 (Publication Type: Letter)

Chemical References

• 2-oxopomolic acid
• 3-O-acetylpomolic acid
• Antineoplastic Agents, Phytogenic
• Triterpenes
• pomolic acid
• Oleanolic Acid
• ursolic acid

Topics

• Animals
• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Chromatography, High Pressure Liquid
• Humans
• Magnetic Resonance Spectroscopy
• Mice
• Oleanolic Acid (analogs & derivatives, chemistry, isolation & purification, pharmacology)
• Peru
• Plant Stems (chemistry)
• Plants, Medicinal (chemistry)
• Triterpenes (chemistry, isolation & purification, pharmacology)
• Tumor Cells, Cultured