Abstract | OBJECTIVES: Genetic factors likely play a role in the etiology of chronic sinusitis and this disease is often associated with diffuse panbronchiolitis, which is strongly associated with HLA B54 antigen. The purpose of this study is to examine whether genetic factors are involved in the pathogenesis of chronic sinusitis. STUDY DESIGN: Eighty-two Japanese patients with intractable chronic sinusitis were selected on the basis of the following criteria: 1) persistent mucous or mucopurulent nasal discharge and/or postnasal dripping for longer than 3 years and 2) opacification in bilateral maxillary sinuses and ethmoid cells in plain X-ray films. METHODS: Both class I and class II HLA antigens were analyzed by conventional microcytotoxicity assays in these patients and 176 healthy control subjects. RESULTS: CONCLUSION: These data indicate that certain genetic factors play a role in the etiology of chronic sinusitis.
|
Authors | K Takeuchi, Y Majima, T Shimizu, K Ukai, Y Sakakura |
Journal | The Laryngoscope
(Laryngoscope)
Vol. 109
Issue 2 Pt 1
Pg. 275-8
(Feb 1999)
ISSN: 0023-852X [Print] United States |
PMID | 10890778
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
|
Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Child
- Chronic Disease
- Female
- HLA-DR Antigens
(immunology)
- Humans
- Japan
(epidemiology)
- Male
- Maxillary Sinusitis
(ethnology, genetics, immunology)
- Middle Aged
|