The ced-8 gene controls the timing of programmed cell deaths in C. elegans.

Abstract	Loss-of-function mutations in the gene ced-8 lead to the late appearance of cell corpses during embryonic development in C. elegans. ced-8 functions downstream of or in parallel to-the regulatory cell death gene ced-9 and may function as a cell death effector downstream of the caspase encoded by the programmed cell death killer gene ced-3. In ced-8 mutants, embryonic programmed cell death probably initiates normally but proceeds slowly. ced-8 encodes a transmembrane protein that appears to be localized to the plasma membrane. The CED-8 protein is similar to human XK, a putative membrane transport protein implicated in McLeod Syndrome, a form of hereditary neuroacanthocytosis.
Authors	G M Stanfield, H R Horvitz
Journal	Molecular cell (Mol Cell) Vol. 5 Issue 3 Pg. 423-33 (Mar 2000) ISSN: 1097-2765 [Print] United States
PMID	10882128 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Apoptosis Regulatory Proteins CED-8 protein, C elegans Caenorhabditis elegans Proteins Calcium-Binding Proteins Ced-4 protein, C elegans Ced-9 protein, C elegans DNA, Helminth Helminth Proteins Membrane Proteins Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-2 Caspases Cysteine Endopeptidases ced-3 protein, C elegans
Topics	Alleles Amino Acid Sequence Animals Apoptosis (genetics) Apoptosis Regulatory Proteins Base Sequence Biological Evolution Caenorhabditis elegans (embryology, genetics) Caenorhabditis elegans Proteins Calcium-Binding Proteins (genetics) Caspases Cloning, Molecular Conserved Sequence Cysteine Endopeptidases (genetics) DNA, Helminth (metabolism) Gene Dosage Genes, Helminth Helminth Proteins (genetics, metabolism) Membrane Proteins (genetics, metabolism) Molecular Sequence Data Mutation Proto-Oncogene Proteins (genetics, metabolism) Proto-Oncogene Proteins c-bcl-2 Sequence Homology, Amino Acid Signal Transduction Time Factors

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