Abstract | PURPOSE: PATIENTS AND METHODS: One hundred twenty-five patients (75 women, 50 men) participated in the study. The time of first perceptible pain relief and meaningful pain relief were measured using a stopwatch technique. Pain intensity and pain relief scores were recorded using standard verbal descriptors at 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 7, and 8 hours after dosing. At the conclusion of the study, patients completed a global evaluation for the effectiveness of the study medication. RESULTS: Both active treatments were superior to placebo for all analgesic measures. Pain relief scores were significantly better for Vicoprofen than placebo throughout the study and significantly better than for acetaminophen with codeine from 2 through 8 hours after dosing. The duration of analgesia (time to remedication) was significantly longer for Vicoprofen (median, 5.50 hours) compared with acetaminophen with codeine (median, 3.03 hours) and placebo (median, 1.00 hours). Mean global evaluation for Vicoprofen was significantly better than for placebo and acetaminophen with codeine. Overall, there were no significant differences in the adverse event profile among the 3 treatment groups. CONCLUSIONS:
|
Authors | V B Ziccardi, P J Desjardins, E Daly-DeJoy, G F Seng |
Journal | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
(J Oral Maxillofac Surg)
Vol. 58
Issue 6
Pg. 622-8
(Jun 2000)
ISSN: 0278-2391 [Print] United States |
PMID | 10847283
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Analgesics
- Drug Combinations
- hydrocodone tartrate, ibuprofen drug combination
- Acetaminophen
- Hydrocodone
- Codeine
- Ibuprofen
|
Topics |
- Acetaminophen
(administration & dosage)
- Adolescent
- Adult
- Analgesics
(administration & dosage)
- Analysis of Variance
- Chi-Square Distribution
- Codeine
(administration & dosage)
- Double-Blind Method
- Drug Combinations
- Drug Evaluation
- Facial Pain
(drug therapy)
- Female
- Humans
- Hydrocodone
(administration & dosage)
- Ibuprofen
(administration & dosage)
- Male
- Molar, Third
(surgery)
- Pain Measurement
- Pain, Postoperative
(drug therapy)
- Statistics, Nonparametric
- Tooth Extraction
(adverse effects)
- Tooth, Impacted
(surgery)
|