Abstract | OBJECTIVES: BACKGROUND: METHODS: We measured flow-mediated dilation of the brachial artery using ultrasound technique in 22 patients with CSA and 20 control subjects. We also evaluated glucose tolerance using a 75-g oral glucose tolerance test and insulin sensitivity using steady-state plasma glucose (SSPG) methods in the same patients. RESULTS: The incidence of impaired glucose tolerance was higher in the CSA group than in the control group. Vitamin C infusion augmented flow-mediated dilation and decreased SSPG levels in the CSA group (from 3.27 +/- 0.77% to 7.00 +/- 0.59% [p < 0.001 by analysis of variance (ANOVA)] and from 177.3 +/- 13.3 to 143.1 +/- 14.9 mg/dl [p = 0.047 by ANOVA], respectively) but not in the control group (from 6.47 +/- 0.66% to 6.80 +/- 0.60% and from 119.8 +/- 11.7 mg/dl to 118.1 +/- 11.3 mg/dl, respectively). The steady-state plasma insulin levels were not affected by vitamin C infusion in either group. CONCLUSIONS:
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Authors | O Hirashima, H Kawano, T Motoyama, N Hirai, M Ohgushi, K Kugiyama, H Ogawa, H Yasue |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 35
Issue 7
Pg. 1860-6
(Jun 2000)
ISSN: 0735-1097 [Print] United States |
PMID | 10841236
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Insulin
- Ascorbic Acid
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Topics |
- Angina, Unstable
(blood, drug therapy, physiopathology)
- Ascorbic Acid
(therapeutic use)
- Blood Glucose
- Endothelium, Vascular
(drug effects, physiopathology)
- Female
- Glucose Tolerance Test
- Humans
- Insulin
(metabolism)
- Male
- Middle Aged
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