[The palatine tonsils and immunity. Report VII. Soluble factors produced by the lymphocytes of the palatine tonsils in vitro].

Abstract

A study was made of the production of a blastogenic factor and lymphotoxin in the cultures of lymphocytes of the palatine tonsils removed from patients with chronic tonsillitis; the activity of this blastogenic factor and lymphotoxin was studied in the test-cultures of autologous and allogenic lymphocytes and the transplantable HeLa cells. The antigens of the pathogenic streptococcus and staphylococcus induced production of the blastogenic factor and lymphotoxin; as to the antigens of saprophytic bacteria-they produced no such action. The antigen-specific blastogenic factor intensified the immune response to the homologous antigen, whereas the factor obtained in stimulation of lymphocytes with PHA-to all the microbial antigens under study.

• Authors: L V Vizirenko, T P Kondrattsova, A E Vershigora
• Journal: Zhurnal mikrobiologii, epidemiologii i immunobiologii (Zh Mikrobiol Epidemiol Immunobiol) Issue 12 Pg. 82-5 (Dec 1975) ISSN: 0372-9311 [Print] Russia (Federation)
• Vernacular Title: Nebnye mindaliny i immunitet. Soobshchenie VII. Rastvorimye faktory, produtsiruemye limfotsitami nebnykh mindalin in vitro
• PMID: 1082697 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antigens
• Lectins
• Lymphotoxin-alpha

Topics

• Antigens
• HeLa Cells
• Humans
• Lectins
• Lymphocytes (immunology)
• Lymphotoxin-alpha (biosynthesis)
• Palatine Tonsil (immunology)
• Staphylococcus (immunology)
• Streptococcus (immunology)