Pituitary adenylate cyclase-activating polypeptide induces hyperthermia in the rat.

Abstract

The effects of centrally administered pituitary adenylate cyclase-activating polypeptide (PACAP-38) on body temperature were investigated in rats. Intracerebroventricular (i.c.v.) administration of PACAP-38 in doses of 500 and 1000 ng induced a dose-related elevation in colon temperature 2, 3, 4, 5 and 6 h after injection. The i.c.v. pretreatment of the animals with different dilutions of PACAP-38 antiserum prevented the development of hyperthermia in PACAP-38-treated animals, whereas PACAP-38 antiserum alone did not modify the colon temperature. An intramuscular injection of noraminophenazone (a cyclooxygenase inhibitor) abolished the PACAP-38-induced hyperthermia. Our data indicate that PACAP may induce hyperthermia via the central nervous system, and this hyperthermic effect may be mediated via a cyclooxygenase-involved pathway.

• Authors: I Pataki, A Adamik, M Jászberényi, M Mácsai, G Telegdy
• Journal: Neuropharmacology (Neuropharmacology) Vol. 39 Issue 7 Pg. 1303-8 (Apr 27 2000) ISSN: 0028-3908 [Print] England
• PMID: 10760372 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adcyap1 protein, rat
• Cyclooxygenase Inhibitors
• Neuropeptides
• Pituitary Adenylate Cyclase-Activating Polypeptide
• Aminopyrine

Topics

• Aminopyrine (pharmacology)
• Animals
• Body Temperature (drug effects)
• Colon (drug effects, physiology)
• Cyclooxygenase Inhibitors (pharmacology)
• Dose-Response Relationship, Drug
• Fever (chemically induced, physiopathology)
• Injections, Intraventricular
• Male
• Neuropeptides (administration & dosage, antagonists & inhibitors, pharmacology)
• Pituitary Adenylate Cyclase-Activating Polypeptide
• Rats
• Rats, Wistar