Abstract | PURPOSE: METHODS: RESULTS: On timolol monotherapy patients with exfoliation glaucoma had a higher mean IOP at 02:00, 06:00, 10:00, 14:00 and 22:00 hour time points as well as a higher maximum, minimum and range of IOP throughout the day compared with the primary open-angle glaucoma group (p < 0.05). Following the addition of dorzolamide as adjunctive therapy to timolol maleate there was a significant reduction in IOP (p < 0.05) at all time points in both glaucomas, but mean IOP at 10:00, 14:00, 18:00 and 22:00 hour time points, as well as the peak and range of IOP, remained higher in the exfoliation glaucoma group. No serious adverse events were noted with dorzolamide. Bitter taste, the most common symptom, was noted in 30% of patients. CONCLUSIONS: These data suggest that dorzolamide 2% used adjunctively with timolol maleate 0.5% solution is effective in reducing diurnal IOP in patients with primary open-angle and exfoliation glaucoma but does not alter the characteristics of higher IOP levels in the latter disease.
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Authors | A G Konstas, A Maltezos, T Bufidis, A G Hudgins, W C Stewart |
Journal | Eye (London, England)
(Eye (Lond))
Vol. 14 ( Pt 1)
Pg. 73-7
(Feb 2000)
ISSN: 0950-222X [Print] England |
PMID | 10755105
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adrenergic beta-Antagonists
- Antihypertensive Agents
- Carbonic Anhydrase Inhibitors
- Sulfonamides
- Thiophenes
- Timolol
- dorzolamide
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Topics |
- Adrenergic beta-Antagonists
(therapeutic use)
- Aged
- Antihypertensive Agents
(therapeutic use)
- Carbonic Anhydrase Inhibitors
(therapeutic use)
- Circadian Rhythm
- Cross-Over Studies
- Drug Therapy, Combination
- Exfoliation Syndrome
(drug therapy)
- Female
- Glaucoma, Open-Angle
(drug therapy)
- Humans
- Male
- Middle Aged
- Prospective Studies
- Sulfonamides
(therapeutic use)
- Thiophenes
(therapeutic use)
- Timolol
(therapeutic use)
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