[The action of anticoagulants on the transmission of the causative agent of plague].

Abstract

The anticoagulants 4-hydrocoumarine and 1,3-indandione derivatives produce a varying action on the formation of a gizzard block in plague-infected fleas. The feeding of fleas on the animals having typical signs of severe intoxication with ratindane, zoocoumarine, and tomorine reduces the time and incidence of gizzard block formation in the fleas. The individuals with blocks retain their high infectability and the development of an infectious process is mainly generalized in rodents. In this connection, the package of eradication measures should involve the concurrent use of insecticides and zoocides which can reduce the size of both rodents and fleas.

• Authors: A P Beĭer, V A Popov, V I Efremenko
• Journal: Meditsinskaia parazitologiia i parazitarnye bolezni (Med Parazitol (Mosk)) 1999 Apr-Jun Issue 2 Pg. 40-3 ISSN: 0025-8326 [Print] Russia (Federation)
• Vernacular Title: Deĭstvie antikoaguliantov na transmissivnuiu peredachu vozbuditelia chumy.
• PMID: 10703205 (Publication Type: Journal Article)

Chemical References

• Anticoagulants

Topics

• Animals
• Anticoagulants (pharmacology)
• Feeding Behavior (drug effects)
• Insect Vectors (drug effects, microbiology)
• Mice
• Plague (microbiology, transmission)
• Rats
• Siphonaptera (drug effects, microbiology)
• Time Factors
• Yersinia pestis (drug effects, pathogenicity)