[The relationship between C-erbB-2 expression with cell proliferative activity and prognosis of nasopharyngeal carcinomas].

Abstract

UNLABELLED:

C-erbB-2 and proliferating cell nuclear antigen (PCNA) were detected by immunohistochemical and in situ hybridization methods in nasopharyngeal carcinomas(NPC) and pericarcinomatous tissues(PCT). Some NPC cases were followed up for more than 5 years.

RESULTS:

The positive rates of C-erbB-2 protein and C-erbB-2 mRNA expression were 87.8%, and 84.0%, respectively in NPC and 74.6% and 76.5%, respectively in PCT. There was a coexpression of C-erbB-2 protein and mRNA. The significant difference for PCNA staining intensity index(S II) existed in the vesico-nuclear and poorly differentiated types of NPC and in the C-erbB-2 staining cases of NPC. No correlation was found between the expression of C-erbB-2 protein and the clinical stage and metastasis as well as survival rate.

CONCLUSION:

The C-erbB-2 gene overexpression and cell abnormal proliferation are associated with the carcinogenesis and development of NPC. It is helpful to examine both C-erbB-2 gene expression and PCNA in NPC to evaluate the malignant degree and the effect of radiotherapy.

• Authors: O Jin, Y Yan, M Shen, R Cheng
• Journal: Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University (Hunan Yi Ke Da Xue Xue Bao) Vol. 23 Issue 3 Pg. 235-8 ( 1998) ISSN: 1000-5625 [Print] China
• PMID: 10681746 (Publication Type: English Abstract, Journal Article)

Chemical References

• Proliferating Cell Nuclear Antigen
• RNA, Messenger
• Receptor, ErbB-2

Topics

• Carcinoma, Squamous Cell (genetics, immunology)
• Cell Division
• Follow-Up Studies
• Humans
• Nasopharyngeal Neoplasms (genetics, immunology)
• Prognosis
• Proliferating Cell Nuclear Antigen (analysis)
• RNA, Messenger (biosynthesis)
• Receptor, ErbB-2 (biosynthesis, genetics)